政府奖惩机制下药品安全质量监管三方演化博弈及仿真分析

药品安全关乎人民群众生命健康、经济发展、社会稳定和国家安全，一直以来都是政府和全社会关注的热点问题之一。但是，近年来频发的各类药品安全事件，揭露了政府监管缺失、药品检测机制不完善、公众投诉失效等诸多问题。本文考虑了药品检测中存在寻租现象，构建了药品生产企业、第三方药品检测机构和政府监管部门之间的三方演化博弈模型，分析了各参与方策略选择的演化稳定性，探讨了各要素对三方策略选择的影响关系，进一步分析了三方博弈系统中均衡点的稳定性。研究结果表明：1)政府增强奖励、惩罚力度均有助于促进企业生产高药效药品、第三方药品检测机构拒绝寻租的规范行为，但是增大奖励力度将不利于政府自身履行监管职责；2)政府设定合理的奖惩机制必须符合对各方的奖惩之和大于其投机收益的条件，才能保障演化稳定市场环境下的药品安全；3)上级政府对监管部门失职的问责对增强企业生产高药效药品的稳健性具有重要意义；4)提升企业的药品销售收益、增加企业寻租成本也是避免企业生产低药效药品的有效途径。最后，利用Matlab 2020b进行了仿真分析，为政府完善药品监管机制提出了对策与建议。     

Factors associated with a positive childbirth experience in Brazilian women: A cross-sectional study

BackgroundHaving a positive childbirth experience is an increasingly valued outcome. Few studies evaluated the women’s satisfaction with childbirth through face-to-face interviews out of the health service environment. The objective of this study was to identify factors associated with a higher level of satisfaction with the childbirth experience among Brazilian women.MethodsThis cross-sectional study involved 287 women giving birth in two hospitals in southern Brazil. Women who gave birth to healthy newborns at term were randomly selected. Face-to-face interviews were conducted 31–37 days after delivery, at the mothers’ homes, using a structured questionnaire. Satisfaction with the childbirth experience was measured using a Likert-type scale ranging from very satisfied to very dissatisfied. Prevalence ratios (PR) were estimated using Poisson regression with robust variance.ResultsFollowing hierarchical multivariate analysis, the following factors remained associated with a higher level of satisfaction with the childbirth experience: being satisfied with antenatal care (PR = 1.30; 95% confidence interval [95%CI] = 1.06−1.59), understanding the information provided by health professionals during labor and delivery (PR = 1.40; 95%CI = 1.01−1.95), not having reported disrespect and abuse (PR = 1.53; 95%CI = 1.01−2.31), and having had the baby put to the breast within the first hour of life (PR = 1.63; 95%CI = 1.26−2.11). No association was observed with type of delivery or hospital status (public or private).ConclusionsA higher level of satisfaction with the childbirth experience is related to satisfactory antenatal care, a non-abusive, respectful, and informative environment during childbirth, and to the opportunity to breastfeed the baby within the first hour of life. In clinical practice, greater attention to these basic principles of care during pregnancy and delivery could provide more positive experiences during birth.     

习近平新时代观的理论生成探讨

理顺习近平关于“中国特色社会主义进入新时代”的逻辑理路，有助于系统论证“新时代”的科学性和理论性。从方法论上看，习近平新时代观是应用马克思主义立场观点和方法得出的正确结论。从理论归因看，中国社会主要矛盾的转化作为习近平新时代观生成的主要标志，源于马克思主义关于矛盾运动的基本理论。从理论定位看，习近平新时代观展现的是中国发展的特殊阶段，内含着中国对自身发展的时代定位与目标趋向，渗透着中国与世界在共同发展中的新阶段、新高度、新未来，是对中国发展方向的顶层设计。     

“百年未有之大变局”之哲学分析

当今世界正处于“百年未有之大变局”中。这是中国共产党对于世界新的时代特征的全新、科学和准确的研判。“百年未有之大变局”这一重大论断，具有深厚的马克思主义哲学的本体论基础、认识论基础、矛盾论基础和历史观基础。作为科学世界观与方法论，马克思主义哲学的辩证唯物主义和历史唯物主义为我们深刻认识和精准把握“百年未有之大变局”的深层本质和哲学依据提供了重要的认知性引导、方法论基础和实践智慧支撑。     

Overcoming barriers: engaging younger students in an online intercultural exchange

This paper reports on a small-scale project involving an online school exchange between two classes of 12-/13-year olds located in the North of England and the Ruhr area of Germany. The overarching aim of the project was to develop intercultural understanding in foreign language learning through communication in an online environment. Analysing data from website posts, lesson observations, student questionnaires and interviews, the paper investigates the extent to which the project realised this goal, and examines emerging practical and pedagogical issues. Comparing the processes and outcomes of this project in secondary education to similar projects in Higher Education (HE), the research found that the young people learnt more than older students about cultural similarities than differences. They were thus less likely to be party to cultural misunderstandings, developing friendly relationships and openness towards a people of a different culture. However, their failure to notice differences may have been due to a lack of in-depth discussion and absence of more demanding student tasks. The paper concludes that in order to develop more sophisticated intercultural learning, expertise derived from telecollaboration in HE needs to be adapted to the lower secondary school context, drawing particularly on auto-ethnography and ethnographic interviewing.     

Field of study variation throughout the college pipeline and its effect on the earnings gap: Differences between ethnic and immigrant groups in Israel

This study demonstrates the analytical leverage gained from considering the entire college pipeline—including the application, admission and graduation stages—in examining the economic position of various groups upon labor market entry. The findings, based on data from three elite universities in Israel, reveal that the process that shapes economic inequality between different ethnic and immigrant groups is not necessarily cumulative. Field of study stratification does not expand systematically from stage to stage and the position of groups on the field of study hierarchy at each stage is not entirely explained by academic preparation. Differential selection and attrition processes, as well as ambition and aspirations, also shape the position of ethnic groups in the earnings hierarchy and generate a non-cumulative pattern. These findings suggest that a cross-sectional assessment of field of study inequality at the graduation stage can generate misleading conclusions about group-based economic inequality among workers with a bachelor’s degree.     

Understanding Gaps Between the Risk Perceptions of Wildland–Urban Interface (WUI) Residents and Wildfire Professionals

Research across a variety of risk domains finds that the risk perceptions of professionals and the public differ. Such risk perception gaps occur if professionals and the public understand individual risk factors differently or if they aggregate risk factors into overall risk differently. The nature of such divergences, whether based on objective inaccuracies or on differing perspectives, is important to understand. However, evidence of risk perception gaps typically pertains to general, overall risk levels; evidence of and details about mismatches between the specific level of risk faced by individuals and their perceptions of that risk is less available. We examine these issues with a paired data set of professional and resident assessments of parcel‐level wildfire risk for private property in a wildland–urban interface community located in western Colorado, United States. We find evidence of a gap between the parcel‐level risk assessments of a wildfire professional and numerous measures of residents’ risk assessments. Overall risk ratings diverge for the majority of properties, as do judgments about many specific property attributes and about the relative contribution of these attributes to a property's overall level of risk. However, overall risk gaps are not well explained by many factors commonly found to relate to risk perceptions. Understanding the nature of these risk perception gaps can facilitate improved communication by wildfire professionals about how risks can be mitigated on private lands. These results also speak to the general nature of individual‐level risk perception.     

Optimization of Cascade‐Resilient Electrical Infrastructures and its Validation by Power Flow Modeling

Large‐scale outages on real‐world critical infrastructures, although infrequent, are increasingly disastrous to our society. In this article, we are primarily concerned with power transmission networks and we consider the problem of allocation of generation to distributors by rewiring links under the objectives of maximizing network resilience to cascading failure and minimizing investment costs. The combinatorial multiobjective optimization is carried out by a nondominated sorting binary differential evolution (NSBDE) algorithm. For each generators–distributors connection pattern considered in the NSBDE search, a computationally cheap, topological model of failure cascading in a complex network (named the Motter‐Lai [ML] model) is used to simulate and quantify network resilience to cascading failures initiated by targeted attacks. The results on the 400 kV French power transmission network case study show that the proposed method allows us to identify optimal patterns of generators–distributors connection that improve cascading resilience at an acceptable cost. To verify the realistic character of the results obtained by the NSBDE with the embedded ML topological model, a more realistic but also more computationally expensive model of cascading failures is adopted, based on optimal power flow (namely, the ORNL‐Pserc‐Alaska) model). The consistent results between the two models provide impetus for the use of topological, complex network theory models for analysis and optimization of large infrastructures against cascading failure with the advantages of simplicity, scalability, and low computational cost.     

A class of additive transformation models for recurrent gap times

Abstract

The gap time between recurrent events is often of primary interest in many fields such as medical studies, and in this article, we discuss regression analysis of the gap times arising from a general class of additive transformation models. For the problem, we propose two estimation procedures, the modified within-cluster resampling (MWCR) method and the weighted risk-set (WRS) method, and the proposed estimators are shown to be consistent and asymptotically follow the normal distribution. In particular, the estimators have closed forms and can be easily determined, and the methods have the advantage of leaving the correlation among gap times arbitrary. A simulation study is conducted for assessing the finite sample performance of the presented methods and suggests that they work well in practical situations. Also the methods are applied to a set of real data from a chronic granulomatous disease (CGD) clinical trial.     

基于消费者显著性偏好的双边平台转换成本和定价策略研究

针对消费者对转换成本和价格属性具有显著性偏好的实际情况，基于显著性理论对垄断双边平台企业的转换成本和定价策略问题进行了研究。研究发现：1)在显著性偏好非对称型市场上，对价格敏感的一方收取的价格最低，对高转换成本的一方收取的价格最高，而在显著性偏好对称型市场上，平台的最优价格位于非对称型市场之间，但是对价格敏感型市场收取的价格低于转换成本敏感型市场的价格。2)在高转换成本的市场，平台利润最低；低转换成本市场平台利润最高，而混合型情况的最优利润位于这两者之间。该研究结论说明平台企业应该采取措施来降低用户加入平台的转换成本，从而增加利润，这与现实的案例研究结论相吻合。